Django on Fly.io with Litestream/LiteFS
I've been playing with Fly.io a lot recently (see my series on deploying Wagtail to Fly.io).
One of the neat things that has come out of Fly is a renewed interest across the dev world in SQLite - an embedded database that doesn't need any special servers or delicate configuration.
Some part of this interest comes from the thought that if you had an SQLite database that sat right next to your application, in the same VM, with no network latency, that's probably going to be pretty quick and pretty easy to deploy.